Publications before 2010

S.-n. Uno, C. Dohno, H. Bittermann, V.L. Malinovskii, R. Häner, K. Nakatani
A Light-Driven, Supramolecular Optical Switch
Angew. Chem. Int. Ed. 2009, 48, 7362-7365. DOI: 10.1002/anie.200903251

V.A. Galievsky, V.L. Malinovskii, A.S. Stasheuski, F. Samain, K.A. Zachariasse, R. Häner, V.S. Chirvony
Photophysical characterization of oligopyrene modules for DNA-based nanosystems
Photochem. Photobiol. Sci. 2009, 8, 1448-1454. DOI: 10.1039/B9PP00016J

T. Meng, C.A. Fuhrer, R. Häner
Synthesis of Furo[3,4-c]furanones via DDQ Treatment of Furo[3,4-c]-pyranone Derivatives
SynLett 2009, 1951-1954. DOI: 10.1055/s-0029-1217525

R. Häner, F. Samain, V.L. Malinovskii
DNA-Assisted Self-Assembly of Pyrene Foldamers
Chem. Eur. J. 2009, 15, 5701-5708. DOI: 10.1002/chem.200900369

H. Bittermann, D. Siegemund, V.L. Malinovskii, R. Häner
Dialkynylpyrenes: strongly fluorescent, environment-sensitive DNA building blocks
J. Am. Chem. Soc. 2008, 130, 15285-15287. DOI: 10.1021/ja806747h

N. Bouquin, V.L. Malinovskii, X. Guégano, S.-X Liu, S. Decurtins, R. Häner
TTF-Modified DNA
Chem. Eur. J. 2008, 14, 5732-5736. DOI: 10.1002/chem.200800505

S. Werder, V.L. Malinovskii, R. Häner
Triazolylpyrenes: Synthesis, Fluorescence Properties and Incorporation into DNA
Org. Lett. 2008, 10, 2011-2014. DOI: 10.1021/ol8006474

N. Bouquin, V.L. Malinovskii, R. Häner

Highly efficient quenching of excimer fluorescence by perylene diimide in DNA

Chem. Commun. 2008, 1974-1976. DOI: 10.1039/B802193G
(This Paper was featured as a "Hot Article")

N. Bouquin, V.L. Malinovskii, R. Häner

Anthraquinones as Artificial DNA Building Block

Eur. J. Org. Chem. 2008, 2213-2219 DOI: 10.1002/ejoc.200800080

F. Samain, V.L. Malinovskii, S.M. Langenegger, R. Häner
Spectroscopic Properties of Pyrene-Containing DNA Mimics
Bioorg. Med. Chem. 2008, 16, 27-33. DOI: 10.1016/j.bmc.2007.04.052

V.L. Malinovskii, H. Bittermann, R. Häner
Self-Organization of Polyaromatic Compounds within DNA
Nucleic Acids Symposium Series 2007, 51, 31-32.

V. Looser, S.M. Langenegger, R. Häner, J. S. Hartig
Pyrene Modification Leads to Increased Catalytic Activity in Minimal Hammerhead Ribozymes
Chem. Commun. 2007, 4357-4359. DOI: 10.1039/B711170C

I. Trkulja, R. Häner
Monomeric and Heterodimeric Triple Helical DNA Mimics
J. Am. Chem. Soc. 2007, 129, 7982-7989. DOI: 10.1021/ja0715501

V.L. Malinovskii, F. Samain, R. Häner
Helical arrangement of interstrand stacked pyrenes in a DNA framework
Angew. Chem. Int. Ed. 2007, 46, 4464-4467. DOI: 10.1002/anie.200790108

G. Bianké, R. Häner
Hairpin Mimics Containing Phenanthroline- and Bipyridine-Derived Linkers
Nucleosides, Nucleotides & Nucleic Acids 2007, 26, 949-952.

R. Messer, C.A. Fuhrer, R. Häner
Transformation of D-(-)-Ribose into a Natural Product-Like Scaffold via a Lewis Acid
Catalyzed Intramolecular Hetero-Diels-Alder Reaction
Nucleosides, Nucleotides & Nucleic Acids 2007, 26, 701-704.

I. Trkulja, A. Stutz, R. Häner
A Phenanthrene Modified RNA Hairpin
Nucleosides, Nucleotides & Nucleic Acids 2007, 26, 879-882.

S.M. Langenegger, V.L. Malinovskii, D. Wenger, S. Werder, R. Häner
DNA Containing Non-Nucleosidic Phenanthrene Building Blocks with Asymmetrical Linkers
Nucleosides, Nucleotides & Nucleic Acids 2007, 26, 901-903.

I. Trkulja, R. Häner
Triple Helix Mediated Excimer and Exciplex Formation
Bioconjugate Chemistry 2007, 18, 289-292. DOI: 10.1021/bc0603283

C.A. Fuhrer, E. Grüter, S. Ruetz and R. Häner
Cis-Stilbene Derived Furopyranones Show Potent Antiproliferative Activity by Inducing G2/M Arrest
ChemMedChem 2007, 2, 441-444. DOI: 10.1002/cmdc.200600284

I. Trkulja, S.M. Biner, S.M. Langenegger and R. Häner
A Molecular Probe for the Detection of Homopurine Sequences
ChemBioChem 2007, 8, 25-27. DOI: 10.1002/cbic.200600378

G. Bianké, V. Chaurin, M. Egorov, J. Lebreton, E. C. Constable, C. E. Housecroft, R. Häner:
Copper Complex-Assisted DNA Hybridization
Bioconjugate Chemistry, 2006, 17, 1441-1446.

S. M. Langenegger, R. Häner:
Selectivity in DNA Interstrand Stacking
Bioorg. Med. Chem. Lett. 2006, 16, 5062-5065.

V.L. Malinovskii, R. Häner:
Synthesis of Polysubstituted Pyrenes with Tuned Spectroscopic Properties for Two-Point Attachment
Eur. J. Org. Chem. 2006, 3550-3553.

N. Guiblin, C. A. Fuhrer, R. Häner, H. Stöckli-Evans, K. Schenk, G. Chapuis:
The incommensurately modulated structure of a tricyclic natural-product-like compound of empirical formula C22H20O3
Acta Cryst. 2006, B62, 506-512.

S. M. Langenegger, R. Häner:
A DNA Mimic Made of Non-Nucleosidic Phenanthrene Building Blocks
ChemBioChem 2005, 6, 2149-2152.

S. M. Langenegger, G. Bianké, R. Tona, R. Häner:
DNA Mimics Containing Non-Nucleosidic Base Surrogates
Chimia 2005, 59, 794-797.

R. Häner:
Modified Oligonucleotides (Editorial)
Chimia 2005, 59, 775.

K. Skobridis, D. Hüsken, P. Nicklin, R. Häner:
Hybridisation and Cellular Uptake Properties of Lipophilic Oligonucleotide-Dendrimer Conjugates
ARKIVOC 2005, 459-469.

R. Messer, X. Pelle, A. L. Marzinzik, H. Lehmann, J. Zimmermann, R. Häner:
Solid Support Synthesis of Natural Product-Like Compounds Derived from D -(-)-Ribose
Synlett 2005, 2441-2444.

R. Tona, R. Häner:
Synthesis and Bioconjugation of Diene-Modified Oligonucleotides
Bioconjugate Chemistry 2005, 16, 837-842.

R. Messer, C. A. Fuhrer, R. Häner:
Natural product-like libraries based on non-aromatic, polycyclic motifs
Curr. Opin. Chem. Biol. 2005, 9, 259-265.

R. Tona, R. Häner:
Crosslinking of Diene-Modified DNA with Bis-Maleimides
Molecular Biosystems 2005, 1, 93-98.

S. M. Langenegger, R. Häner:
Remarkable Stabilization of Duplex DNA Containing an Abasic Site by Non-Nucleosidic Phenanthroline and Pyrene Building Blocks
ChemBioChem 2005, 6, 848-851.

S. M. Langenegger, R. Häner:
Excimer Formation by Interstrand Stacked Pyrenes
Chem. Commun. 2004, 2792-2793.

D. Ackermann, R. Häner:
Non-Nucleosidic Base Surrogates: The Effect of 1,2-Disubstituted Phenanthrenes on DNA Stability
Helv. Chim. Acta 2004, 87, 2790-2804.

S. M. Langenegger , R. Häner:
DNA containing phenanthroline- and phenanthrene-derived, non-nucleosidic base surrogates
Tetrahedron Lett. 2004, 45, 9273-9276.

R. Messer, A. Schmitz, L. Moesch, R. Häner:
Elaboration of D-(-)-Ribose into a Tricyclic, Natural Product-like Scaffold
J. Org. Chem. 2004, 69, 8558-8560.

R. Tona, R. Häner:
Functionalization of Diene-Modified Hairpin Mimics via the Diels-Alder Reaction
Chem. Commun. 2004, 1908-1909.

J.-P. Bianké, R. Häner:
A Metal-Coordinating DNA Hairpin Mimic
ChemBioChem 2004, 5, 1063-1068.

C. A. Fuhrer, R. Messer, R. Häner:
Stereoselective Synthesis of 3a,7a-Dihydro-3H,4H-furo[3,4-c]pyran-1-ones via Intramolecular Hetero-Diels-Alder Reaction
Tetrahedron Lett. 2004, 45, 4297-4300.

S. M. Langenegger, R. Häner:
A Simple, Non-Nucleosidic Base Surrogate Increases Duplex Stability of DNA Containing an Abasic Site
Chem. Biodiv. 2004, 1, 259-264.

S.M. Langenegger, L. Moesch, F. Natt, J. Hall, R. Häner:
A novel oxime-derived solid support for the synthesis of 3'-phosphorylated oligonucleotides
Helv. Chim. Acta 2003, 86, 3476-3481.

A. Stutz, S. M. Langenegger , R. Häner:
Phenanthrene-derived DNA hairpin mimics
Helv. Chim. Acta 2003, 86, 3156-3163.

D. Hüsken, F. Asselbergs, B. Kinzel, J. Weiler, P. Martin, F. Natt, R. Häner,

J. Hall:
Fusion mRNA constructs serve for a general cell-based assay to profile oligonucleotide activity
Nucleic Acids Res. 2003, 31, e102.

S. M. Langenegger, R. Häner:
The effect of a non-nucleosidic phenanthrene building block on DNA duplex stability
Helv. Chim. Acta 2002, 85, 3414-3421.

L. Canaple, D. Hüsken, J. Hall, R. Häner:
Artificial Ribonucleases: Efficient and Specific in vitro Cleavage of human c-raf-1 RNA
Bioconjugate Chemistry 2002, 13, 945-951.

S. A. Rushworth, C. A. Bravery, J. Hall, F. Natt, N. J. Parsons, J. Weiler, R. Häner, S. Thompson:
Inhibition of CD40 mediated endothelial cell activation using antisense oligonucleotides
Transplantation 2002, 6, 2547-2555.

R. Häner:
Artificial Ribonucleases
Chimia 2001, 55, 1035-1037. R. Häner:
Oligonucleotide Technology - a Research Platform for Chemical Biology
Chimia 2001, 55, 285-289.

A. P. Simoes-Wüst, R.A. Olie, O. Gautschi, S. H. Leech, R. Häner, J. Hall, D. Fabbro, R .A. Stahel U. Zangemeister-Wittke:
bcl-xl Antisense treatment induces apoptosis in breast carcinoma cells
Int. J. Cancer 2000, 87, 582-590.

U. Zangemeister-Wittke, S. H. Leech, R. A. Olie, A. P. Simoes-Wüst, O. Gautschi, G. H. Luedke, F. Natt, R. Häner, P. Martin, J. Hall, C. M. Nalin,

R. A. Stahel:
A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells
Clinical Cancer Research  2000, 6, 2547-2555.

S. H. Leech, R. A. Olie, O. Gautschi, A. P. Simoes-Wüst, S. Tschopp, R. Häner, J. Hall, R. A. Stahel, U. Zangemeister-Wittke:
Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment
Int. J. Cancer 2000, 86,  570-576.

R. Häner, D. Hüsken, J. Hall:
Development of Artificial Ribonucleases using Macrocyclic Lanthanide Complexes
Chimia 2000, 54, 569-574.

D. Hüsken, A. Deichert, J. Hall, R. Häner:
Combinatorial Library of Artificial Ribonucleases
Nucleosides & Nucleotides 1999, 18, 1507-1511.

A.O. Schaffhauser, S. Whitebread, R. Haener, K.G. Hofbauer, A. Stricker-Krongrad:

Neuropeptide Y Y1 receptor antisense oligodeoxynucleotides enhance food intake in energy-deprived rats
Regul. Pept. 1998, 75-76, 417-423.

J. Hall, R. Häner, S. Aime, M. Botta, S. Faulkner, D. Parker, A.S. de Sousa:
Relaxometric and Luminescence Behavior of Triaquohexaazamacrocyclic Complexes, the Gadolinium Complex Displaying a High Relaxivity with a Pronounced pH Dependence
New J. Chem. 1998, 22, 627-631.

R. Häner, J. Hall, A. Pfützer, D. Hüsken:
Development of Artificial Ribonucleases
Pure and Applied Chemistry 1998, 70, 111-116.

J. Hall, D. Hüsken, R. Häner:
Sequence-Specific Cleavage of RNA Using Novel Macrocyclic Lanthanide Complexes Conjugated to Oligonucleotides: a Structure Activity Study
Nucleosides & Nucleotides 1997, 16, 1357-1368.

R. Häner, J. Hall:
Sequence-Specific Cleavage of RNA with Artificial Chemical Ribonucleases
Antisense and Nucleic Acids Drug Development 1997, 7, 423-430.

F. Natt, R. Häner:
Use of a Lipophilic Phosphoramidite-based Capping Reagent to Facilitate Oligonucleotide Purification
Tetrahedron 1997, 53, 9629-9636.

M. Scherr, C. Klebba, R. Häner, A. Ganser, J.W. Engels:
Synthesis and Properties of Hammerhead Ribozymes Stabilized Against Nucleases by Different 2'-Modifications: Methoxyethoxy-, Fluoro- and Amino-Groups
Bioorg. Med. Chem. Lett. 1997, 7, 1791-1796.

R. Häner, J. Hall, G. Rihs:
Synthesis and Structure of a Macrocyclic Europium Complex and Its Possible Role as a Catalyst for Phosphodiester Transesterification
Helv. Chim. Acta 1997, 80, 487-494.

D. Hüsken, G. Goodall, M.J.J. Blommers, W. Jahnke, J. Hall, R. Häner, H.E. Moser:
Creating RNA Bulges: Cleavage of RNA in RNA/DNA Duplexes by Metal Ion Catalysis
Biochemistry 1996, 35, 16591-16600.

M. Fogel-Petrovic, S. Vujcic, R. Häner, U. Regenass, H. Mett, C.W. Porter:
Sequence Specific Antisense Oligonucleotide Interference with Spermidine/Spermine N 1 -Acetyltransferase Gene Expression
Anticancer Research 1996, 16, 2517-2524.

J. Hall, D. Hüsken, R. Häner:
Towards Artificial Ribonucleases: the Sequence-Specific Cleavage of

RNA in a Duplex
Nucleic Acids Research 1996, 24, 3522-3526.

K.-H. Altmann, N.M. Dean, D. Fabbro, S.M. Freier, T. Geiger, R. Häner, D. Hüsken., P. Martin, B.P. Monia, M. Müller, F. Natt, P. Nicklin, J. Phillips, U. Pieles, H. Sasmor, H.E. Moser:
Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals
Chimia 1996, 168-176.

R. Häner, J. Hall, D. Hüsken, H.E. Moser:
Sequence-Specific Cleavage of RNA Using Lanthanide Complexes Linked to Oligonucleotides , in B. Meunier (ed.) DNA Cleavers and Chemotherapy of Cancer and Viral Diseases
Nato ASI Series, 1996, 307-320.

C. García-Echeverría, R. Häner:
A Convenient Method for the Preparation of Oligonucleotide 5'-Phosphates
Tetrahedron 1996, 52, 3933-3938.

A. De Mesmaeker, R. Häner, P. Martin, H.E. Moser:
Antisense Oligonucleotides
Acc. Chem. Res. 1995, 366-374.

J. Hall, D. Hüsken, U. Pieles, H.E. Moser, R. Häner:
Efficient sequence-specific cleavage of RNA using novel europium complexes conjugated to oligonucleotides
Chemistry & Biology 1994, 1, 185-190.

T.H. Keller, R. Häner:
Synthesis and hybridization properties of oligonucleotides containing 2'-O-modified ribonucleotides
Nucleic Acids Research 1993, 21, 4499-4505.

T.H. Keller, R. Häner:
A General Method for the Synthesis of 2'-O-Modified Ribonucleosides
Helv. Chim. Acta 1993, 76, 884-892.

R. Häner, P.B. Dervan:
Single-Strand DNA Triple-Helix Formation
Biochemistry 1990, 29, 9761-9765.
P. Dunn, R. Häner, H. Rapoport:
Stereoselective Synthesis of 2,3-Diamino Acids. 2,3-Diamino-4-phenylbutanoic Acid
J. Org. Chem. 1990, 55, 5017-5025.

R. Häner, B. Olano, D. Seebach:
Preparation and C-Alkylation of Enantiomerically Pure S-Phenyl Aziridinecarbothioates. On the Structure of Small-Ring Ester Lithium Enolates
Helv. Chim. Acta 1987, 70, 1676-1693.

D. Seebach, R. Häner, T. Vettiger:
Nucleophile Ringöffnung von a -Nitrocyclopropan-carbonsäure-arylestern mit sterisch geschützter, aber elektronisch wirksamer Carbonyl- und Nitro-Gruppe. Ein neues Prinzip der a-Aminosäure-Synthese (2-Aminobutansäure-a 4 -Synthon)
Helv. Chim. Acta 1987, 70, 1507-1515.

D. Seebach, R. Häner:
C-Alkylation of Phenylthio Aziridine Carboxylates
Chem. Lett. 1987, 49-52.

R. Häner, T. Maetzke, D. Seebach:
Generation and Reactions of Lithiated tert-Butyl and 2,6-Di(tert-butyl)-4-methylphenyl Cyclopropanecarboxylates
Helv. Chim. Acta 1986, 69, 1655-1665.

R. Häner, W.B. Schweizer, P. Seiler, D. Seebach:
Aldol Addition of a Lithium Ketone Enolate with Persubstituted Double Bond - a Reversal of the Usual Stereochemical Course
Chimia 1986, 40, 97-98.

R. Häner, D. Seebach:
Nitration of the DBHA Cyclopropanecarboxylate Enolate - A New and Efficient Route to 1-Aminocyclopropane-1-carboxylic Acid
Chimia 1985, 39, 356-357.

R. Häner, T. Laube, D. Seebach:
Regio- and Diastereoselective Preparation of Aldols from ?-Branched Ketone Enolates Generated from BHT Ester Enolates and Organolithium Reagents - In Situ Generation and Trapping of Ketenes from Ester Enolates
J. Am. Chem. Soc. 1985, 107, 5396-5403.

R. Häner, T. Laube, D. Seebach:
Reversal of Product Configuration in Michael Additions of Lithium Enolates to E- and Z-1-Nitro-1-propene
Chimia 1984, 38, 255-257.

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